In Vivo Fibrinolytic Activity and Pharmacology of Various Plasmin (Fibrinolysin) Preparations

In vivo fibrinolytic activity and pharmacology of various plasmin (fibrinolysin) preparations.

A quantitative method based on the disappearance of I laljeled fibrin h;is been used to study the in vivo effect of fibrinolytic agents. Various preparations of human and bovine plasmin were found to lyse clots effectively. The minimal effective dose of human plasmin prepared by the method of Kline was 15 Loomis units/Kg. Plasmin preparations given intravenously produced hypotension and leukope...

Fibrinolysin ( Plasmin ) Therapy in Acute Deep Thrombophlebitis

THE magnlitude of the literature dealing with deep thrombophlebitis of the lower extremities and its complications reflects not onily the interest that this disorder commands among physicians but also the extensive controversy that it has generated. Controversy surrounds even such fundamental problems as the pathogenesis of venous thromboembolism, the natural course of the process, and the adeq...

Fibrinolysin ( Plasmin ) Therapy in Acute Deep

THE magnlitude of the literature dealing with deep thrombophlebitis of the lower extremities and its complications reflects not onily the interest that this disorder commands among physicians but also the extensive controversy that it has generated. Controversy surrounds even such fundamental problems as the pathogenesis of venous thromboembolism, the natural course of the process, and the adeq...

Study on the effect of streptokinase-activated plasmin (fibrinolysin) on clots in various stages of organization.

Fibrinogenolytic and fibrinolytic activity of cell-associated plasmin.

Binding of plasmin(ogen) to rat C6 glioma cells is saturable and kringle-domain dependent. This interaction was studied as a model of plasmin(ogen) receptor interactions in nucleated mammalian cells. Apparent 125I-plasmin dissociation from C6 cell binding sites was slow; however, the dissociation rate was increased when the solution contained diisopropyl phosphoryl-plasmin (0.3 microM), fibrino...